Intranasal route delivery system pdf
Intranasal administration has drawn much attention on account of the efficacy of nasal delivery of drugs to the central nervous system, as reported by many studies.
Intranasal administration of elastin-like polypeptide for therapeutic delivery to the central nervous system Jeremy WD McGowan,1 Qingmei Shao,1 Parminder JS Vig,1,2 Gene L Bidwell III1,2 1Department of Neurology, 2Department of Biochemistry, University of Mississippi Medical Center, Jackson, MS, USA Abstract: Bypassing the blood–brain
While nasal delivery is possible the majority of the time, to overcome these delivery issues a number of device have been developed that enhance delivery – these are discussed in the delivery techniques section of this web site.
delivery are not available to most caregivers, and rectal diazepam, the most common home therapy, is expensive and often ineffective, new routes of administration are needed. This review examines recent research suggesting that intranasal administration of midazolam is at least as
Intranasal medication administration offers a non-invasive alternative route in medication delivery when other routes are not available or will result in an unacceptable delay in medication effectiveness.
The history of nasal drug delivery dates back to earlier topical applications of drugs intended for local effects. The early 1980s saw the introduction of nasal route as a promising systemic delivery alternative to other conventional drug delivery routes . Intranasal drug delivery has many advantages over other routes of drug administration.
One of the oldest nasal delivery systems is nasal drops (Kublik and Vidgren, 1998). When administered correctly, nasal drops may spread over a larger area than nasal sprays, but are often cleared faster than nasal sprays as well ( Hardy et al., 1985 ).

suggested that the skin and the buccal and nasal mucous membranes may have use as alternate routes of analgesic and anesthetic drug delivery. A novel transmucosal delivery system for …
review deals with the utility of the nasal route for the delivery of drugs to the brain as a microemulsion system in the treatment of a number of ailments like migraine,
Strategies for intranasal delivery of vaccines Mehfuz Zaman Saranya Chandrudu Istvan Toth 0 ) School of Pharmacy, The University of Queensland , Brisbane, QLD, Australia The vast majority of human pathogens colonize and invade at the mucosal surfaces.
Keywords: Intranasal drug delivery, Brain targeting, Protein & Peptides, Liposomes, Microspheres. INTRODUCTION: In ancient times the Indian Ayurveda system of medicines used nasal route for administration of drug and the
Naleen Bhandari, Intranasal medication delivery overview.ppt – Download as Powerpoint Presentation (.ppt), PDF File (.pdf), Text File (.txt) or view presentation slides online.

Intranasal delivery to the central nervous system




Naleen Bhandari Intranasal medication delivery overview

Intranasal drug delivery – General principles The nasal cavity’s easily accessible, rich vascular plexus permits topically administered drugs to rapidly achieve …
Our results suggest that the new microemulsion system may be useful for getting rapid-onset of midazolam and diazepam following intranasal administration, resulting in reasonable peak plasma levels and bioavailability, but most importantly, providing a high measure of tolerability and comfort.
Abstract: The aim of the study was mainly to investigate the relationship between concentration of rivastigmine and its inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) following intranasal (IN) and intravenous (IV) administration in rats, and to provide a novel nasal delivery route for the brain disease therapy.
drug delivery via the nasal route can also apply at the local level – which is sometimes overlooked; many of the drug technologies and strategies employed for systemic drug action can also be used locally. Interestingly, of the approximately 27 nasal products currently on the market, 17 are prescribed for local effect (1). This article provides a brief overview of the anat-omy of the nose


Review Article A Review on Intranasal Drug Delivery System Pagar Swati Appasaheb*, ABSTRACT Shinkar Dattatraya Manohar, Delivery of drugs through nasal route has been potentially explored as an alternative route Saudagar Ravindra Bhanudas1 for
The efficacy of vaccine delivery was assessed via the intranasal and oral routes. The vaccine formulation was coadministered with a bacterial toxin as mucosal adjuvant or was administered without additional adjuvant. Control mice were included to address the specificity of the immune response and contribution of the LCP component to vaccine efficacy. We evaluated the immunogenicity of the
This bypassing of the gastrointestinal system even enables the delivery of peptide hormones . Calcitonin and desmopressin are on the market for years now; insulin and glucagon were under clinical development for this administration route [ 2 ].
Present review highlights the potential of nasal mucosa as an administration route for targeting the central nervous system, the brain. Targeted drug delivery seeks …
The blood–brain barrier (BBB) is a major impediment to the therapeutic delivery of peptides and proteins to the brain. Intranasal delivery often provides a non-invasive means to bypass the BBB.


intranasal delivery to the CNS, with a discussion of pathways from the nasal cavity to the CNS involving the olfactory and trigeminal nerves, the vasculature, the cere- brospinal fluid, and the lymphatic system.
Routes of Delivery. Choosing a delivery route, targeting the CNS, Also in early stage development is a formulation for intranasal delivery of hPTH-(1–34). Initiatives by Chugai Pharmaceuticals and a separate collaboration between Procter & Gamble and Nastech are directed at developing a nasal spray. This noninvasive delivery system is currently being readied for a phase III clinical
A therapeutic composition of lorazepam and its pharmaceutically acceptable derivatives are provided for intranasal administration of at least one predetermined volumetric unit dose in the form of a spray by means that delivers one or more therapeutically prescribed unit doses that are highly accurate as to the volume discharged and which leave
The intranasal drug route is more than just an administration route. There are unique benefits for IN delivery. The anatomy of the nasal mucosa allows for rapid drug absorption, and its location
Nasal drug administration has been used as an alternative route for the systemic availability of drugs restricted to intravenous administration. This is due to the large surface area, porous
The article highlights the importance and advantages of the drug delivery systems applied via the nasal route, which have bioadhesive properties. Bioadhesive, or more appropriately, mucoadhesive systems have been prepared for both oral and peroral administration in the past. The nasal mucosa presents an ideal site for bioadhesive drug delivery systems. In this review we discuss the effects of
Turker S, Onur E, Ozer Y (2004) Nasal Route and Drug Delivery Systems. Pharmacy World and Science 26(3): 137–42 Crossref , Google Scholar Vyas TK, Shahiwala A, Marathe S et al. ( 2005 ) Intranasal Drug Delivery for Brain Targeting .
Intranasal drug delivery is considered as a lucrative route of drug delivery system for formulation scientist because of its easy and simple formulation strategies.
SNBL is developing its μcoTM System for nasal formulation and delivery of small-molecule and protein therapeutics, and intranasal vaccines. In this piece, Shunji Haruta, PhD, Executive
Nasal route for the delivery of some drugs offers an alternative in the pharmaceutical industry. The present review deals with the utility of the nasal route for the delivery of drugs to the brain as a microemulsion system in the treatment of a number of ailments like migraine, epilepsy, and hypertension. The nasal route could be important for drugs that are used in crisis treatments, such …

Tissue Distribution and Pharmacodynamics of Rivastigmine

drug delivery. Through intranasal route, first pass metabolism is avoided. The specialized anatomy and physiology of the nasal cavity and its ready accessibility make the nasal cavity a particularly attractive delivery site for the systemic administration of drugs like other epithelia due to its large surface area. The permeability of the nasal epithelium to drug molecules varies greatly
GUIDELINE ON THE DELIVERY OF INTRANASAL MEDICATION USING MAD (MUCOSAL ATOMISER DEVICE) Version GUIDELINE ON THE DELIVERY OF INTRANASAL MEDICATION USING MAD (MUCOSAL ATOMISER DEVICE) Reference Number: DIMMMAD-08-2016-AMcDGOC-V2 Version Number: V2 Date of Issue: August 2016 Page 3 of 8 Department of Nurse Practice Development 1.0 Introduction The Intranasal route …
A study of rivastigmine liposomes for delivery into the brain through intranasal route. The present study is mainly aimed at delivering a drug into the brain via the intranasal route …
Abstract. Since ancient times, drugs have been administered via the nasal route for therapeutic and recreational purposes. The interest in, and importance, of the systemic effects of drugs administered through the nasal route, have expanded over recent decades.

Intranasal drug delivery General principles

The interest in intranasal delivery of drugs as a non‐invasive is increased. We have the systemic circulation through nasal drug delivery system. 8. Convenient route when compared with parenteral route for long term therapy.
effective but has poor compliance.6 The intranasal route for midazolam has been used since 1988 and has the advantage of rapid absorption directly into the systemic circulation with no first-pass effect and a bioavailability of 55–83%.7–10 However, the delivery method appears to be poorly tolerated and threaten- ing, with poor retention of drops and drainage into the post-nasal space.11
In recent decades the interest in intranasal drug administration is increased, not only for the treatment of acute and chronic diseases of the nasal cavity but mainly for drug delivery to the brain.
molecules Article Investigation of Absorption Routes of Meloxicam and Its Salt Form from Intranasal Delivery Systems Csilla Bartos 1, Rita Ambrus 1, Anita Kovács 1, Róbert Gáspár 2 …
Chitosan-alginate microparticulate delivery system for an alternative route of administration of BCG vaccine Liliana Aranha Caetano 1,2, Rita Amaral 2, Lara Figueiredo , …
Historically, intranasal drug delivery has been utilized for local treatments such as allergies, etc. Recently, the use of intranasal route as a means of delivering therapeutics to the CNS has gained tremendous interest and momentum .

DRUG DELIVERY & FORMULATION Drug delivery via the nose


Brain Uptake of Neurotherapeutics after Intranasal versus



explored as a delivery system to enhance CNS uptake across nasal mucosa. Addition of mucoadhesive agent such as a polyelectrolyte polymer helps in retention of formulation in nasal cavity that further facilitates the absorption. The retention is due to the electronic interaction between mucin of nasal mucosa and the polymer (Rhee et al., 2007). Evidences of intranasal drug delivery systems
Nasal administration is a route of administration in which drugs are insufflated through the nose. It can be a form of either topical administration or systemic administration , as the drugs thus locally delivered can go on to have either purely local or systemic effects.
Joe McDonough, Michael Ladika, in Handbook of Non-Invasive Drug Delivery Systems, 2010. 8.4.3 Other polymers. Different strategies have been explored to increase the bioavailability following nasal administration for hydrophilic and high-molecular-weight drugs.
A Review on Intranasal Drug Delivery System INTRODUCTION The history of nasal drug delivery dates back to earlier topical applications of drugs intended for local effects. Nasal therapy also called ‘Nasya karma’ has been recognized form of treatment in the Ayurvedic system of Indian medicines [1]. The early 1980s saw the introduction of nasal route as a promising systemic delivery
Recent trends in drug delivery systems: Intranasal drug delivery Varsha Agarwal & B. Mishra Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, Varanasi 221005, India Nasal route of drug delivery is commonly known for treatment of …
Using the intranasal delivery system, researchers have demonstrated neuroprotective effects in different animal models of stroke using erythropoietin (EPO) as a …
A variety of compounds will distribute into the brain when placed at the cribriform plate by intranasal (i.n.) administration. In this study, we investigated the ability of albumin, a protein that can act as a drug carrier but is excluded from brain by the blood-brain barrier, to distribute into the brain after i.n. administration. We labeled
Introduction. Intranasal delivery is a non-invasive route for drugs that are active in low doses and show no or minimal oral bioavailability. A wide variety of therapeutics compound may be administered intranasally for local, systemic and central nervous system (CNS) action (Dhuria et al., 2010 Dhuria SV, Hanson LR, Frey WH.
Intranasal drug delivery has evolved in the recent years as a significant method of delivering drugs through the nasal route. This method has been identified to have all the potential to achieve significant milestones in the pharmaceutical industry, as it is largely driven by its capability to cure local infections and chronic allergies.
delivery system is not yet clearly established. Relatively inconvenient to patients when compared to oral delivery systems since there is a possibility of nasal irritation.

Intranasal Drug Administration — An Attractive Delivery


Strategies for intranasal delivery of vaccines (pdf

Delivery System for Intranasal Administration of Olanzapine route for drug delivery. Orally disintegrating wafers and intramuscular (IM) injection of OLZ are available to overcome the bioavail-ability problems because of extensive first-pass metabolism after oral administration (Kumar et al. 2008). The approved indications for OLZ IM injection are to rapidly control agit-ation and
A REVIEW ON INTRANASAL DRUG DELIVERY SYSTEM: TARGETING BRAIN Sunita Sharma NRI Vidyadayani Institute of Science, Management and Technology (Received on Date: 15 January 2018 Date of Acceptance: 28 March 2018) ABSTRACT In spite of a few restrictions, intranasal conveyance is by all accounts the most encouraging application to enhance CNS issue, including. Medications …
The intranasal (IN) route of medication administration is a recognised to be a useful and reliable form of drug delivery comparable to oral and parenteral routes. This anatomical, physiological and histological characteristics of the nasal
In conclusion, these studies demonstrate that the intranasal route of administration has great potential as a means of delivery to the brain of therapeutic proteins that would otherwise be excluded by the BBB. Furthermore, the use of cationic liposomes as a delivery system may promote brain transport and extend residence time to ultimately improve therapeutic efficacy of the intranasally
Intranasal route of drug delivery is a promising route of drug delivery into the brain, which might be augmented using suitable carrier systems like liposomes, thereby enhancing CNS penetration of drugs and also delivering drugs in a

Use of intranasal drug administration in the pre-hospital

A study of rivastigmine liposomes for delivery into the

Intranasal Medication Administration

Nasal route and drug delivery systems SpringerLink


Intranasal administration A prospective drug delivery

Intranasal Drug Administration An Innovative Approach to

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